In Vivo ADME

Sekisui XenoTech offers a full suite of preclinical in vivo ADME services and features an in vivo team with over 40 years of experience. Our in vivo ADME facility in Japan features clean rooms for cell culture, an animal care facility and a large variety of instrumentation to support both radiolabeled and unlabeled investigations for preclinical in vivo and in vitro studies. Sekisui XenoTech's Japanese facility is a fully accredited AAALAC facility.


Radio-Labeled Synthesis
Whole-Body Autoradiography

Study Capabilities

14C, 3H, 33S, 35S, 90Y, 125I and 111In

Mouse, rat, guinea pig, rabbit, dog, minipig, marmoset and monkeys

Single and multiple dosing

Administration routes
Oral, intravenous, continuous intravenous, transdermal, subcutaneous, intramuscular, intratracheal, instillation, intrarectal and intraduodenal

- Drug plasma concentration
- Absorption site investigation

- Tissue distributions (over 30 organs)
- QWBA (Quantitative Whole Body Autoradiography)
- Micro-autoradiography
- Plasma protein binding
- Blood/plasma partition rate
- Placental transfer

- Metabolite analytical method set-up
- Metabolic profile (plasma, urine, bile and tissues)
- Metabolite identification

- Excretion rate (urine, feces, expiration air and bile)
- Enterohepatic circulation
- Lymphatic partition rate
- Excretion into milk

Additional options available:
- Custom RI synthesis
- Purification of labeled compound
- Customized report
and more....
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