In Vivo ADME

Sekisui XenoTech offers a full suite of preclinical in vivo ADME services and features an in vivo team with over 40 years of experience. Our in vivo ADME facility in Japan features clean rooms for cell culture, an animal care facility and a large variety of instrumentation to support both radiolabeled and unlabeled investigations for preclinical in vivo and in vitro studies. Sekisui XenoTech's Japanese facility is a fully accredited AAALAC facility.

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Pharmacokinetics
Radio-Labeled Synthesis
Whole-Body Autoradiography


Study Capabilities

Isotopes
14C, 3H, 33S, 35S, 90Y, 125I and 111In

Species
Mouse, rat, guinea pig, rabbit, dog, minipig, marmoset and monkeys

Administration
Single and multiple dosing

Administration routes
Oral, intravenous, continuous intravenous, transdermal, subcutaneous, intramuscular, intratracheal, instillation, intrarectal and intraduodenal

Absorption
- Drug plasma concentration
- Absorption site investigation

Distribution
- Tissue distributions (over 30 organs)
- QWBA (Quantitative Whole Body Autoradiography)
- Micro-autoradiography
- Plasma protein binding
- Blood/plasma partition rate
- Placental transfer

Metabolism
- Metabolite analytical method set-up
- Metabolic profile (plasma, urine, bile and tissues)
- Metabolite identification

Excretion
- Excretion rate (urine, feces, expiration air and bile)
- Enterohepatic circulation
- Lymphatic partition rate
- Excretion into milk

Additional options available:
- Custom RI synthesis
- Purification of labeled compound
- Customized report
and more....
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