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CryostaX® PooledHuman Hepatocytes for Suspension

CryostaX® is the largest multi-donor pool available using a single-freeze process, designed to provide long-term consistent results, extensive characterization, the highest possible enzymatic activity, and on-demand custom-pooling.

Your suspension assays are faster and easier when you use CryostaX®

Utilizing CroystaX® Pooled Human Hepatocytes for Suspension

CryostaX® features two different pool sizes, plus custom on-demand options based on individual enzyme activities and/or donor demographics from over 200 potential donors. Whatever your study requires, SEKISUI XenoTech can meet your needs with a wide variety of pooled primary human hepatocytes ready for your in-house in vitro work.

Our patented format highlights our commitment to efficiency without sacrifice to quality; CryostaX® hepatocyte pellets go through one cryopreservation cycle rather than two (as is typical of traditional vial format), the thawing process is simplified to enable you to go from storage to assay in fewer steps, and our streamlined ordering process gives you all the information you need–including upfront pricing–to choose the perfect lots for your assays. 

Our hepatocyte expertise stems from decades of preparing these test systems for our own contract research. Utilizing the hepatocytes that we produce in our own contract studies allows an added level to quality control beyond the standard characterization that most hepatocytes vendors provide.

Zell Woodworth, Products Division Director at SEKISUI XENOTECH

Simplified Thawing Procedure

With CryostaX®, thawing is easy. Download our thawing protocol or watch the demo to the right to get the best results out of your cryopreserved hepatocytes:

Extensive Characterization

Enzyme Marker SUBSTRATE REACTION
CYP1A2 Phenacetin O-dealkylation
CYP2B6 Bupropion hydroxylation
CYP2C8 Amodiaquine N-dealkylation
CYP2C9 Tolbutamide
CYP2C19 S-Mephenytoin 4′-hydroxylation
CYP2D6 Dextromethorphan O-demethylation
CYP3A4/5 Midazolam 1′-hydroxylation
UGT 7-Hydroxycoumarin glucuronidation
SULT 7-Hydroxycoumarin sulfonation
OATP1B1 Esterone sulfate
OATB1B3 CCK-8
OCT1 MPP+
NTCP TCA

On-Demand Custom Pooling

An example of no-charge custom pooling of CryostaX® is shown below. By characterizing each individual donor, SEKISUI XenoTech enables you to pick from an extensive list of available tissue and design your own pools. By using the characterization data it is possible to determine a quick snapshot of the designed pool’s overall activities.

CryostaX Hepatocyte Activities

Match your test systems with the right media

Our formulas are optimized to give you the best results from your suspension hepatocytes….

Study director analyst in vitro ADME studies