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Drug Drug Interactions (DDI)

Are in vitro drug metabolism and drug-drug interaction studies critical for an IND?

A Guide to What, Why & When to Conduct ADME Studies When drug developers are preparing their IND, drug metabolism...

4 Ways De-Risking Maximizes Compound Value

Since most new drugs fail because of ADME/Tox, you can add considerable value to your compound by conducting early in...

New FDA Draft Guidance “Clinical Pharmacology Considerations for the Development of Oligonucleotide Therapeutics” – XenoTech’s perspective on in vitro DDI testing

The FDA has released a new draft guidance for industry titled “Clinical Pharmacology Considerations for the Development of Oligonucleotide Therapeutics.”...

Spotlight on Efflux and Uptake Drug Transporters in In Vitro Drug-Drug Interaction Studies

What are drug transporters? Drug transporters are membrane-bound proteins that assist in the movement of drugs into or out of...

When, Why and How to Conduct CYP2C Induction Studies

Over the years, we have received a lot of questions about cytochrome P450 (CYP) 2C induction studies. In February of...

Why Do Most Polled Researchers Run Red Blood Cell Partitioning Studies with Plasma Protein Binding?

Many compounds bind to or diffuse into red blood cells (RBCs), which can significantly impact clearance and cause inaccuracies in PK calculations...

Highlights from the 2021 Marbach Drug-Drug Interaction Workshop

Reflecting on the virtual conferences in 2021, I would like to look back at some of the highlights from the...

2021 Service Expansions: Microsomal Protein Binding and Red Blood Cell Partitioning

Over the course of 2021, we expanded access to two important and related study offerings at our US laboratory headquarters....

ADME/PK & DDI Best Practices Industry Survey Results & Infographic

With over 3500 respondents, only 4% of respondents said they had never experienced any repercussions from postponing these studies...

Four Ways CROs Drive Innovation for Improved In Vitro Drug Metabolism and Pharmacokinetics (DMPK) Studies

Agility and focused growth allow drug developers to outsource expertise and benefit the industry at-large by fostering innovation. Panelists at the 2021 Annual DMDG Meeting…

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