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Drug Drug Interactions (DDI)

Why Do Most Polled Researchers Run Red Blood Cell Partitioning Studies with Plasma Protein Binding?

Pharmacokinetic (PK) parameters of new drug candidates are traditionally determined by measuring drug concentration in plasma. However, many compounds bind to...

Highlights from the 2021 Marbach Drug-Drug Interaction Workshop

Reflecting on the virtual conferences in 2021, I would like to look back at some of the highlights from the...

ADME/PK & DDI Best Practices Industry Survey Results & Infographic

We recently ran an industry survey to help us understand what the current industry standards are for when and why...

Four Ways CROs Drive Innovation for Improved In Vitro Drug Metabolism and Pharmacokinetics (DMPK) Studies

Agility and focused growth allow drug developers to outsource expertise and benefit the industry at-large by fostering innovation. Panelists at the 2021 Annual DMDG Meeting…

DDI & Drug Repurposing Article featured in Drug Discovery World (DDW) Spring Edition 2021

Repurposing (repositioning, re-profiling, or re-tasking) a drug potentially saves years of costly testing from going to waste and potentially providing a higher chance of success.…

Interview with Outsourcing Pharma: Repurposing existing drugs accelerates discovery

“Exploring alternative uses for drugs tapped for other indications, can save considerable time and money in discovery, according to an...

Drug-Drug Interaction (DDI) Prediction Models Following In Vitro Studies in Preclinical Development

In preclinical development, a drug will be evaluated for potential to cause a drug-drug interaction (DDI) using in vitro experiments and then calculations that...

Important DDI Considerations for Repurposing Drugs to Treat COVID-19

“Given the rapid spread of COVID-19 and its relatively high mortality, filling the gap for coronavirus-specific drugs is urgent. […]...

What is DMPK and how does it fit into drug development?

Drug metabolism and pharmacokinetics (DMPK) is a core discipline in drug development that considers the biotransformation of a drug compound...

ADME and Drug-Drug Interactions for the Toxicologist

Highlights from the recent webinar presented by our newest expert consultant, Dr. Pallavi Limaye In her recent webinar (now available for...

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