December 2017

What to Do with Microsome Stable, Low-Turnover Compounds

Author: Dr. Chris Bohl Posted: 07 December 2017

Compounds that exhibit high metabolic stability in hepatocytes and subcellular fractions can be a challenge for ADME scientists. These in vitro drug metabolism test systems are easy to source and use at the bench, and the methods for xenobiotic metabolism in these matrices are largely standardized and accepted by the scientific community, but they are limited to a 4-6 hour window of time when they are metabolically active and can generate quality data. There have been many interesting advances in the field to address these constraints, though...

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