July 2017

Sekisui XenoTech's Analytical Services Department Adds New Instrumentation

Author: Michael Millhollen Posted: 17 July 2017

Sekisui XenoTech's Analytical Services lab provides researchers with custom method development and method validation, dose solution analysis, in vitro and in vivo metabolite profiling studies, small-molecule non-GLP bioanalysis and more utilizing specialized equipment, including a Waters Xevo TQ-S mass spectrometer and Xevo G2-XS quadrupole time-of-flight (QTof) mass spectrometer...

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Considerations When Studying Esterase Activities in the Intestine

Author: Dr. Chris Bohl, Michael Millhollen Posted: 11 July 2017

First-pass metabolism in the gut is commonly associated with CYP450 and UGT enzymes, however, it may be important for you to consider the impact of intestinal esterases on your compound. Utilizing a PMSF-free preparation for your test system maintains high levels of esterase activity to ensure reliable experimental results, but is less useful for CYP450 metabolism studies due to low activities...

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