November 2019

What In Vitro Metabolism and DDI Studies Do I Actually Need?

Author: Madison Knapp, Greg Loewen Posted: 25 November 2019

While there may not be a set ‘roadmap’ spelling out the studies required to achieve regulatory approval of every drug candidate, recent documents published by FDA, EMA, and PMDA highlight several in vitro studies evaluating metabolism and potential for drug-drug interaction...

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In Vivo ADME Expertise Providing Cost Savings

Author: Scott Hickman Posted: 19 November 2019

Over 10 years ago, SEKISUI and the expertise of the Tokai Drug Development Solutions Center in Japan merged with XenoTech in Kansas City, KS. This adjoining was a marriage made from similar values and the shared importance of quality, experience and expertise. If you haven’t worked with our Tokai laboratory, we don’t want you to miss out on the incredible value of this famous laboratory. So we have lowered pricing on many of our in vivo services so you can experience the same quality studies they have always offered but at a reduced price...

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Mass Balance Studies: What You Need and Why You Need It

Author: Jolanta Golec, Madison Knapp Posted: 15 November 2019

In vivo mass balance studies are an important element of nonclinical drug development, to inform first in-human (FIH) studies and to understand the pharmacokinetic (PK) profile of a drug. Not only do you need it for dosimetry calculations to determine appropriate radiolabeled dose in human absorption, metabolism, and excretion (hAME) studies, but lucidating PK properties can help bridge activity and toxicity data to paint a full picture of a drug’s behavior in patient populations...

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Meet the Scientist: Rachel Murphy, PhD

Author: Michael Millhollen Posted: 06 November 2019

We thought it might be nice to put faces to the names of some of the scientists you interact with at SEKISUI XenoTech, so we're recording video interviews with various team members about what it's like working here and what motivates them to do what they do. In this interview, Dr. Murphy discusses how our foundational 3S principles influence her daily work life...

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