CryostaX® Plateable Pools

Current Promotions

CryostaX-Plateable-Pools.jpg


CryostaX® Plateable Pooled human hepatocytes offer a simple, cost-effective test system for metabolic clearance, hepatic uptake / transporter studies and CYP induction screening studies. All of our CryostaX® products are developed with a patented single-freeze process (Patent 9,642,355) which minimizes cryoinjury and promotes high viability and cell yield.

CryostaX® Plateable Pools are available as standard pools of 5 or 10 donors or as custom-designed pools (at no additional charge) with donors selected specifically based on individual enzyme activities and/or donor demographics from over 200 potential donors. CryostaX® Plateable Pools meet Sekisui XenoTech's stringent culture criteria, maintaining good confluency and morphology for at least five days.

This product is ideal for:

  • Metabolic Stability of Low, Mid & High Clearance Drugs
  • Hepatic Uptake & Transporter Studies
  • CYP Induction Screening
  • Various In Vitro Hepatotoxicity Endpoints

View the CryostaX® Plateable Pools Flyer (Page 2)


Characterization Provided

 
Enzyme Marker Substrate Reaction
CYP1A2 Phenacetin O-dealkylation
CYP2B6 Bupropion hydroxylation
CYP2C8 Amodiaquine N-dealkylation
CYP2C9 Tolbutamide
CYP2C19 S-Mephenytoin 4'-hydroxylation
CYP2D6 Dextromethorphan O-demethylation
CYP3A4/5 Midazolam 1'-hydroxylation
UGT 7-Hydroxycoumarin glucuronidation
SULT 7-Hydroxycoumarin sulfonation
OATP1B1 Esterone sulfate
OATB1B3 CCK-8
OCT1 MPP+
NTCP TCA
*Intrinsic clearance data is also included
 


*Representative lot of CryostaX® Plateable Pools


Features and Benefits

  • Only single-freeze, pooled plateable human hepatocyte product available
  • Patented single-freeze process minimizes cryoinjury
  • Each donor is significantly represented in the final pooled product
  • Easy, single-step thawing process
  • Extensively characterized for metabolism and uptake transport
  • Custom on-demand pooling at no additional charge
  • Highly competitive pricing

View Sekisui XenoTech's cryopreserved hepatocyte thawing and plating protocol here. Buy cell and tissue based products
Product Description Volume AMY
HPCH05+ CryostaX, Pooled Plateable Human Hepatocytes, 5 mill AMY Each 5 million
HPCH10+ CryostaX, Pooled Plateable Human Hepatocytes 10 donor, AMY 5 million Each 5 million
Or Create a Custom Pool
What criteria would you like to use to create your custom pool?
Use*:
Specific Enzyme Activity
Assured Minimum Yield (AMY)
Pool Size
BMI
Disease State
Age, Ethnicity &/or Gender
Alcohol, Tobacco &/or Drug Use
Serologies
Name / Company*:
Email / Phone*:
Find the Cellular Products You Need  
Can't find what you need? Have a question?
Use the Form Above
Or Call 1-877-588-7530
(+1.913.438.7450 International)

 
Contact Us

Contact Us

Questions or inquiries? Use our contact form and we’ll reply as soon as possible.* indicates required field

Request A Quote
Request A Quote

Request A Quote

 Security code