Blog

Cold Storage Solution Linked to Lower AO, XO Activity

Author: Michael Millhollen Posted: 22 August 2017

Allopurinol, UW cold storage solution has been shown to reduce aldehyde oxidase and xanthine oxidase activity in common human liver test systems for in vitro drug metabolism studies…

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Considerations in Response to Drug-Drug Interaction Guidances

Author: Michael Millhollen Posted: 17 August 2017

Sekisui XenoTech scientists contributed to the published considerations from the IQ Induction Working Group in response to drug-drug interaction guidances from regulatory agencies...

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URI Drug Transporters Workshop Presentations

Author: Michael Millhollen Posted: 11 August 2017

If you couldn't make it to The University of Rhode Island College of Pharmacy's 5th Annual Transporters in Drug Discovery and Development: Driving Knowledge from Laboratory to Label (TDDD 2017), you can still view our presentations...

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New Division Directors for Core Services and Services Logistics Appointed

Author: Michael Millhollen Posted: 01 August 2017

Following the promotion of Dr. Joanna Barbara, Ph.D., to Vice President of Scientific Operations, Dr. Etsuko Usuki, Ph.D., has been promoted to the position of Division Director for Sekisui XenoTech's Core Services. Andrea Wolff has also been appointed to the newly created position of Division Director for Sekisui XenoTech's Services Logistics...

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Sekisui XenoTech's Analytical Services Department Adds New Instrumentation

Author: Michael Millhollen Posted: 17 July 2017

Sekisui XenoTech's Analytical Services lab provides researchers with custom method development and method validation, dose solution analysis, in vitro and in vivo metabolite profiling studies, small-molecule non-GLP bioanalysis and more utilizing specialized equipment, including a Waters Xevo TQ-S mass spectrometer and Xevo G2-XS quadrupole time-of-flight (QTof) mass spectrometer...

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Considerations When Studying Esterase Activities in the Intestine

Author: Michael Millhollen Posted: 11 July 2017

First-pass metabolism in the gut is commonly associated with CYP450 and UGT enzymes, however, it may be important for you to consider the impact of intestinal esterases on your compound. Utilizing a PMSF-free preparation for your test system maintains high levels of esterase activity to ensure reliable experimental results, but is less useful for CYP450 metabolism studies due to low activities...

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UGT activities, concomitant drugs, and DDI

Author: Michael Millhollen Posted: 20 June 2017

Do you have questions or concerns about how your compound may affect UGT induction and/or inhibition when combined with other therapeutic regiments? We can help address those concerns...

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New range of Pig P450s Bactosomes

Author: Isabelle Nobiron, tebu-bio Posted: 19 June 2017

If you are looking for enzymatic in vitro tools for drug metabolismreaction phenotyping or metabolite generation using a pig model, you may find these newly released Pig Bactosomes from Cypex of interest...

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Metabolite production made fast and easy – BMO Kits

Author: Isabelle Nobiron, tebu-bio Posted: 14 June 2017

Metabolite characterization can be a lengthy process making your in vitro drug testing time consuming and expensive. Whether you are working on phase I or phase II metabolic enzymatic reactions, take a look at these BMO kits which can help you speed up this characterization process...

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New Liver Disease Resource & Other Research Biobank News

Author: Michael Millhollen Posted: 26 May 2017

Download the new FLD progression infographic: Characteristics of Normal and Fatty Liver Disease Tissues, or read about the new gallbladder tissue as well as liver tissue samples from donors diagnosed with steatosis and steatohepatitis along with additional details on NASH and Diabetic donors...

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Big Hepatocytes News!

Author: Michael Millhollen Posted: 10 May 2017

Sekisui XenoTech was issued U.S. Patent No. 9,642,355 for the “CRYOPRESERVATION OF CELLS AND SUBCELLULAR FRACTIONS” and enhanced its catalog of hepatocyte offerings...

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New VP of Scientific Operations and VP of Scientific Consulting Appointed

Author: Michael Millhollen Posted: 04 May 2017

Sekisui XenoTech has appointed Dr. Joanna Barbara as Vice President of Scientific Operations and Dr. Brian Ogilvie as Vice President of Scientific Consulting...

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New Lysosome Catabolism Protocol and Tech Tips

Author: Michael Millhollen Posted: 17 April 2017

New guide available: IgG Catabolism Protocol & Lysosome / Tritosome Technical Tips… 

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Sekisui XenoTech Adds New Drug Transporters to Portfolio

Author: Michael Millhollen Posted: 01 April 2017

Sekisui XenoTech features the most extensive selection of drug transporters and assays available in the world, and now we have added 6 more to the list...

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Sekisui Turns 70 This Month!

Author: Michael Millhollen Posted: 03 March 2017

From a single plastics manufacturing plant in Japan to a diverse, multi-billion-dollar, global family which includes Sekisui XenoTech in Kansas City, Sekisui Chemical Group has positioned itself as a corporate leader in key industries and a strong advocate for environmental issues. XenoTech joined the Sekisui team in 2008 to bring focused expertise on biotransformation and preclinical development consulting to the broad range of pharmaceutical development services offered by Sekisui.

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Sekisui XenoTech Named Best for Pharmaceutical Safety Testing 2017

Author: Michael Millhollen Posted: 02 March 2017

Sekisui XenoTech has been named the Best for Pharmaceutical Safety Testing in the 2017 Biotechnology Awards. “This awards programme recognises the hard work and dedication of the firms, and the individuals behind them, that are driving innovation in this vital market. It has been my honour to recognise these dedicated professionals and I would like to wish them the very best of fortunes for the future...”

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Sekisui XenoTech Adds New Dermal Subcellular Fraction Test Systems

Author: Michael Millhollen Posted: 01 February 2017

Sekisui XenoTech now offers human, minipig, mouse and rat dermal microsomes or S9 fractions as in stock standard test systems for the development of safer new products delivered to or through the skin. Subcellular fractions are widely used in drug discovery and preclinical drug development to evaluate the in vitro metabolism of new therapeutics.

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Pharmaceutical Outsourcing Magazine Interview Nov-Dec 2016

Author: Michael Millhollen Posted: 29 November 2016

Pharmaceutical Outsourcing Magazine interviewed Chris Bohl, PhD, Global Technical Support Manager for Sekisui XenoTech’s Products Division, on the company and what's new...

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Sekisui XenoTech Standardizes Lysosomal Test Systems for Biopharmaceutical Development

Author: Michael Millhollen Posted: 05 October 2016

Sekisui XenoTech now offers hepatic human lysosomes and rat tritosomes as standard test systems. These products contain high concentrations of lysosomal degradative enzymes and constitute advantageous test systems for analysis of catabolism and/or activation for targeted biopharmaceuticals that enter cells through the endosomal-lysosomal pathway...

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Sekisui XenoTech Joins Fight Against Liver Disease

Author: Michael Millhollen Posted: 16 September 2016

Currently, there are no approved therapies for NASH, yet nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) affects 1-in-4 people worldwide. Research BioBank provides disease-defined liver tissue samples and hepatocytes as a convenient human model for hepatic disease research...

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Sekisui XenoTech Hepatotox News Featured on Outsourcing Pharma

Author: Michael Millhollen Posted: 09 August 2016

Outsourcing Pharma reached out to us after we released an announcement that we had expanded our hepatotoxicity screening services to protect our customers from costly drug candidate failures from liver injury further down the development pipeline. Drug induced liver injury is one of the leading causes of adverse events in clinical trials...

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Sekisui XenoTech Featured on Labiotech.EU

Author: Michael Millhollen Posted: 05 July 2016

In the article, titled "Understand which transporters are involved in a drug’s absorption, distribution & excretion," Labiotech.EU's editors collaborated with our team to discuss: "How can you build the best case for a new drug application to the regulatory agencies? Preclinical studies are a crucial part in determining the pharmacokinetics of a drug – and more specifically how it is going to interact with drug transporters. So reaching out to the leading provider and consultant in this area (with strong academic roots) is the logical step at this stage of development..."

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XenoTech Scientists Publish Paper, Present Research Evaluating Ketoconazole and its Alternative Clinical CYP3A4-5 Inhibitors as Inhibitors of Drug Transporters

Author: Michael Millhollen Posted: 25 April 2016

Sekisui XenoTech scientists published a paper in Drug Metabolism and Disposition evaluating Ketoconazole and its alternative clinical CYP3A4-5 inhibitors as inhibitors of drug transporters, and presented their research at a meeting of the Delaware Valley Drug Metabolism Discussion Group (DVDMDG), during a webinar earlier this month, and with a poster at the AAPS/ITC Workshop on Drug Transporters.

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Sekisui XenoTech Fulfills Largest Order To Date

Author: Michael Millhollen Posted: 01 February 2016

Sekisui XenoTech recently fulfilled its largest order of human liver subcellular fractions to date. A large pharmaceutical customer ordered over 30,000 vials of microsomes, 5000 vials of S9 fractions and 5000 vials of cytosol.

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XenoTech Hosts Bring Your Kids to Work Day

Author: Matt Beck Posted: 04 May 2015

XenoTech hosted "Bring your kids to work" day on April 23rd.

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XenoTech Executives Take the Ice Bucket Challenge to Benefit ALS

Author: Matt Beck Posted: 22 August 2014

XenoTech employees raised over $1,400 in a single day to benefit the ALS Association. Watch the video of the Ice Bucket Challenge by clicking on the link to read more!

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XenoTech Promotes Environmental Responsibility

Author: Christian Darabant Posted: 14 August 2014

XenoTech employees embrace Sekisui Environmental Week

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XenoTech Company Halloween

Author: Matt Beck, Marketing Manager Posted: 01 November 2013

Happy Halloween, XenoTech style! Enjoy some pictures from this year's festivities.

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Navigating the Transporter Wave of 2013: A Review of the Seven ITC Publications on Drug Transporters

Author: Greg Loewen, Principal Scientist - Drug Transport Posted: 28 August 2013

The International Transporter Consortium (ITC) issued seven papers in the July 2013 issue of Clinical Pharmacology & Therapeutics. These seven papers summarize the current understanding of transporters as related to possible drug-drug interactions (DDI). Although there is a mountain of research focusing on many aspects of drug transport such as the transport of endogenous compounds, transport regulation, characterizing transporter function, targeting transporters for disease treatment, etc. these papers outline the information most drug development companies need to know to investigate possible DDIs and properly label their compounds to prevent transporter based DDIs. Since the FDA issued the 2006 “Guidance for Industry, Drug Interaction Studies…” which described the in vitro assays suggested to predict possible P-gp related DDIs, the ITC published a white paper in 2010, the EMA issued the draft “Guideline on the Investigation of Drug Interactions” in 2010 and both the FDA and EMA published updated guidelines in 2012. The most recent guidelines described seven transporters that should be studied for possible DDIs, the in vitro assays used to study those transporters and decision trees to help decide if clinical studies were warranted to further elucidate possible DDIs. The seven papers published in July discuss the clinical importance of the MATE transporters, the clinical importance of OATP1B1 and BCRP polymorphisms, the applicability of the decision trees with some examples of compounds approved since the decision trees were published, in vitro methods used to study transporters, intercellular drug concentrations, kinetic parameters in conjunction with translational modeling, and why DDIs at the blood brain barrier are unlikely. A summary of the focus and main points of each of the seven papers can be found by clicking "Read More" below. To view our webinar on the seven papers click here

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