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test systems

Fresh Primary Human Hepatocytes

Fresh human hepatocytes are available in suspension or plated on collagen-coated plates and offer an alternative to in vivo or cryopreserved hepatocytes. Hepatocyte preparations are delivered in vial format for suspension or on collagen-coated plates with a Matrigel overlay for plated/attaching cells.

Fresh human hepatocytes from liver tissue can help drug developers explore their drug candidate’s metabolism

Because of the time-sensitive nature of fresh human hepatocyte products, we only offer them when human donor tissue is received; however, fresh animal hepatocytes can be prepared upon request as a Custom Preparation.

Enzyme Marker Substrate Reaction plated or Suspension
CYP1A2 Phenacetin O-dealkylation Plated
CYP2B6 Bupropion hydroxylation Plated
CYP3A4 Midazolam 1′-hydroxylation Plated
CYP 7-Ethoxycoumarin O-dealkylation Suspension
UGT 7-Hydroxycoumarin glucuronidation Suspension
SULT 7-Hydroxycoumarin sulfonation Suspension

*Includes Isolation Viability

Be Prepared

Download a thorough guide put together by our in-house specialists to help you make the most of your fresh human hepatocytes.

Test article small molecule drug ADME