Hepatocytes

Hepatocytes are commonly used in drug discovery and preclinical drug development to perform experiments requiring intact cellular systems. Intact hepatocytes contain the major hepatic drug-metabolizing enzymes required to study the four categories of xenobiotic biotransformation: hydrolysis, reduction, oxidation and conjugation. Because of these enzymes, hepatocytes provide a viable and cost-effective alternative to in vivo testing.
 
As the industry leader in hepatic cells and tissue-derived products for drug metabolism studies, Sekisui XenoTech offers the widest variety of hepatocyte cell lines, with pool sizes ranging from individual donors to HepatoSure®, Sekisui XenoTech’s 100-donor hepatocyte pool and the largest hepatocyte pool commercially available.
 
Sekisui XenoTech offers a variety of hepatocytes from humans and animals...
Buy cell and tissue based products
Human Hepatocyte Cells:
Geneknown™ Hepatocytes (pooled genotyped hepatocytes)
HepatoSure® Pooled Human Hepatocytes (100-donor cryopreserved hepatocyte pools)
CryostaX® Pooled Human Hepatocytes (single-freeze, customizeable pools)
CryostaX® Pooled Plateable Human Hepatocytes (single-freeze, customizeable pools)
Cryoplateable Human Hepatocytes (individual donor attaching hepatocytes)
Ready-Plate® Human Hepatocytes (pre-plated hepatocytes)
Single-Donor Human Hepatocytes (individual donor suspension hepatocytes)
Qualyst Transporter Certified™ Plateable Human Hepatocytes
Fresh Human Hepatocytes
Immortalized Hepatocytes (hepatocyte cell lines, JCRB also available)
Disease-Diagnosed Hepatocytes

Animal Hepatocyte Cells:
Cryoplateable Animal Hepatocytes (pooled attaching hepatocytes)
Cryopreserved Animal Hepatocytes (pooled suspension hepatocytes)
Ready-Plate® Animal Hepatocytes (pre-plated hepatocytes)
Fresh Animal Hepatocytes

Custom Hepatocyte Preparations
 
Hepatocyte Media:
Optimized Hepatocyte Thawing, Plating, Overlay, Incubate and Culture Media
 

Unsure of which test system you need? Check our Guide to Selecting In Vitro Test Systems for Pre-Clinical Studies or contact us for guidance!
 

Additional Resources:
Hepatocyte Cellular Product Flyers:

Download XenoTech’s Human Hepatocyte Flyer
Download XenoTech’s Animal Hepatocyte Flyer

Hepatocyte Protocols:
Download our Hepatocyte Thawing & Plating Protocol
View our Hepatocyte Thawing & Plating Demo Videos

Hepatocyte Scientific Resources:
Poster: 
Hepatocytes Are the Preferred Test System to Evaluate Oligonucleotide-CYP Interactions In Vitro​
Poster: A Comparative Investigation of Benzo[a]pyrene, Procaine and Nevirapine Metabolism in Human Hepatocytes and a 3D Skin Tissue Model
Poster: The Impact of Various Solvents and Solvent Concentrations on In Vitro Enzyme Induction Assessment in Cultured Human Hepatocytes
Poster: Assessment Under Initial Rate Conditions of the Selectivity and Time Course of Cytochrome P450 Inactivation in Pooled Human Liver Microsomes and Hepatocytes
Poster: Effects of Albumin-Fused Human Growth Hormone TV-1106 on CYP Enzyme Expression in Human Hepatocytes
Poster: The Effect of Buffer Ionic Strength or Various Media on the In Vitro Metabolism of Cytochrome P450 Substrates in Pooled Human Liver Microsomes and Cryopreserved Human Hepatocytes
Poster: The Use of Pooled Plated Cryopreserved Human Hepatocytes for the Determination of Metabolic Clearance, Cytochrome P450 Enzyme Induction and Uptake Transporter Studies
Paper: Anti-CD28 Monoclonal Antibody-stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6 and CYP3A4 in Human Hepatocytes In Vitro​
Paper: In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal
Poster: Determination of Low Intrinsic Clearance Values using Primary Human Hepatocytes and the HepaRG® Cell Line
Poster: Test system-dependent clearance of CYP2D6 and CYP3A4/5 substrates
Poster: Time-course of Cytochrome P450 (CYP450) induction in cultured human hepatocytes
Poster: Midazolam clearance in human hepatocytes is restricted compared with human liver microsomes but not by cell permeability or cofactor availability
Webinar: Application of Hepatocytes for In Vitro Uptake Assays
Poster: Temporal changes in CYP3A4 mRNA and activity following treatment of cultured human hepatocytes with interleukin-6 (IL-6)
Poster: In situ evaluation of CYP1A2, CYP2B6 and CYP3A4/5 induction in cultured human hepatocytes with a cocktail of probe substrates
Poster: The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes

View more research...
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